Prenylated xanthones from the root bark of Cudrania tricuspidata

J Nat Prod. 2007 Jul;70(7):1207-9. doi: 10.1021/np070059k. Epub 2007 Jul 4.

Abstract

Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / enzymology
  • Mice
  • Molecular Structure
  • Monoamine Oxidase Inhibitors / chemistry
  • Monoamine Oxidase Inhibitors / isolation & purification*
  • Monoamine Oxidase Inhibitors / pharmacology
  • Moraceae / chemistry*
  • Plant Bark / chemistry
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Xanthones / chemistry
  • Xanthones / isolation & purification*
  • Xanthones / pharmacology

Substances

  • Monoamine Oxidase Inhibitors
  • Xanthones